Carnosine supplement review 250 mg, 500 mg dosage, benefit as antioxidant, for
cataract and Parkinson's disease, this nutrient has a number of health benefits
that are just beginning to be explored
March 3 2014
Carnosine (beta-alanyl-L-histidine) is a natural antioxidant found in the body and also available through foods and supplements. It can help reduce glycation.
Camosine is a naturally occurring, water-soluble dipeptide. It has buffering activities in excitable animal and human tissues, exhibits metal ions binding properties, antioxidant and antiglycating properties, extends the life-span of cultured human diploid cells, regulates sarcoplasmic reticulum calcium-release channel activity. Carnosine may be a potential therapeutic agent (neurodegenerative, metabolic, cardiovascular diseases) mainly due to its antioxidant and antiglycating activities.
Carnosine is sold in various dosages, most commonly as 500 mg.
Carnosine supplement pills 30 capsules 500 mg
Dose: you may use one capsule in the morning a couple of times a week, there is no need to take it every day.
Carnosine is found exclusively in animal tissues, such as brain and skeletal muscle tissues. It is a potent hydrophilic antioxidant, antiglycating agent, reactive oxygen species scavenger and pH-buffer. Carnosine has potential benefits in many diseases of central nervous system, such as Alzheimer's disease, Parkinson's disease and cerebral ischemic diseases. Only a few human studies have been published regarding the health benefits. The early research looks quite promising.
Athletics and exercise
Using carnosine and natural antioxidants for the prophylaxis of acute post-loading oxidative stress
Eksp Klin Farmakol. 2007.
The effects of a submaximum single physical load with a mixed aerobic-anaerobic character (combined rowing test) on the intensity of lipid peroxidation (LPO) processes, antioxidant state of the organism, and rheological properties of blood have been studied in a group of athletes. The administration of natural antioxidants significantly decreased the LPO stress induced by the physical load, reduced the suppression of the antioxidant system of the organism, and normalized the LPO-disturbed hemorheological parameters. Antioxidants such as carnosine, cytamine, and apilac can be used as non-doping means for the accelerated recovery and increase in the physical work capacity in athletes.
Medical treatment of cataract.
Clin Experiment Ophthalmol. 2007; Toh T, Morton J, Coxon J. Department of Ophthalmology, Christchurch Hospital, Christchurch, New Zealand.
Since the last major review of medical treatment of cataract the search for an anti-cataract agent has advanced on many fronts. Some anti-cataract drugs, such as carnosine, have now reached clinical trials and showed encouraging results that warrant further investigation.
Liver protection from the harm of alcohol abuse
The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats.
Hum Exp Toxicol. 2010. Artun B, Küskü-Kiraz Z, Gulluoglu M, Cevikbas U, Koçak-Toker N. Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Oxidative stress plays an important role in pathogenesis of alcohol-induced liver injury. In this study, we investigated the effect of carnosine pretreatment on ethanol-induced oxidative stress and hepatotoxicity. Rats were given carnosine (2 g/L in drinking water) for 4 weeks and then ethanol was administered orally to rats at a dose of 5 g/kg every 12 hours for 3 doses totally (binge model). Plasma alanine (ALT) and aspartate (AST) transaminase activities and liver triglyceride, malondialdehyde (MDA), diene conjugate (DC), glutathione (GSH), vitamin E and vitamin C levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities were determined. Binge ethanol administration resulted in significant increases in plasma transaminase activities, hepatic triglyceride and lipid peroxide levels. However, GSH, vitamin E, vitamin C levels and GSH-Px and GST activities were found to be decreased following ethanol administration. Macromicrovesicular steatosis was also seen. Carnosine pretreatment appeared to prevent the increase of plasma ALT and AST activities and hepatic MDA and DC levels following ethanol treatment. In addition, hepatic GSH levels increased, but there were no changes in triglyceride, vitamin E, vitamin C levels and SOD, GSH-Px and GST activities, following ethanol treatment in carnosine-pretreated rats. There was also no change in liver histopathological appearance. In conclusion, carnosine prevented the increases in serum transaminase activities and lipid peroxides in liver of ethanol-treated rats, without any change on steatosis in liver.
Carnosine increases efficiency of DOPA therapy of Parkinson's disease: a pilot study.
Rejuvenation Res. 2008: Boldyrev A, Fedorova T, Stepanova M, Dobrotvorskaya I, Boldanova N, Bagyeva G, Ivanova-Smolenskaya I, Illarioshkin S. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
The addition of the neuropeptide carnosine as a food additive to the basic protocol of Parkinson's disease treatment results in significant improvement of neurological symptoms, along with increase in red blood cell Cu/Zn-SOD and decrease in blood plasma protein carbonyls and lipid hydroperoxides, with no noticeable change in platelets MAO B activity. The combination of carnosine with basic therapy may be a useful way to increase efficiency of PD treatment.
Carnosine side effects, is it safe?
No major side effects have been reported in medical journals with this dipeptide supplement. One short term adverse effect is alertness and shallow sleep when very high dosages are supplemented.